Ligand clusters for UniProt code P42345

Ligand clusters for P42345: Serine/threonine-protein kinase mTOR from Homo sapiens

		Top 6 (of 18) ligand clusters Cluster 1. 4 ligand types 15 ligands Cluster 2. 7 ligand types 16 ligands Cluster 3. 1 ligand type 1 ligand Cluster 4. 1 ligand type 2 ligands Cluster 5. 2 ligand types 3 ligands Cluster 6. 2 ligand types 2 ligands
Representative protein: 6zwmA

Structures

PDB		Schematic diagram
6zwmA
6zwoB
5flcB
4jt5B
4jspB
		more ...

Cluster 1 contains 4 ligand types

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Ligand		Description
		1. Ligand: RAP × 9 sirolimus Rapamycin immunosuppressant drug PDB codes: 1fap(B), 4drh(B), 4dri(B), 4drj(B), 5flc(B), 5gpg(B), 6m4u(B), 6m4w(G).
		2. Ligand: RAD × 2 C49-Methyl rapamycin PDB codes: 1nsg(B), 2fap(B).
		3. Ligand: ARD × 2 C15-(R)-Methylthienyl rapamycin PDB codes: 3fap(B), 4fap(B).
		4. Ligand: SO4 × 2 Sulfate ion PDB codes: 4drh(E),

Cluster 2 contains 7 ligand types

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Ligand		Description
_Mg		1. Metal: _MG × 6 PDB codes: 3jbz(A), 4jsp(B), 4jsv(B),
		2. Ligand: AGS × 3 Phosphothiophosphoric acid-Adenylate ester PDB codes: 4jsp(B), 6zwm(A), 6zwo(B).
		3. Ligand: ADP × 2 Adenosine-5'-Diphosphate PDB codes: 3jbz(A), 4jsv(B).
		4. Ligand: MGF × 2 Trifluoromagnesate PDB codes: 3jbz(A), 4jsv(B).
		5. Ligand: 17G × 1 9-(6-Aminopyridin-3-Yl)-1-[3-(Trifluoromethyl) phenyl]benzo[h][1,6]naphthyridin-2(1h)-One PDB code: 4jsx(B).
		6. Ligand: P2X × 1 2-[4-Amino-1-(Propan-2-Yl)-1h-Pyrazolo[3,4-D]pyrimidin- 3-Yl]-1h-Indol-5-Ol PDB code: 4jt5(B).
		7. Ligand: X6K × 1 3-(4-Morpholin-4-Ylpyrido[3',2':4,5]furo[3,2- D]pyrimidin-2-Yl)phenol PDB code: 4jt6(B).

Cluster 3 contains 1 ligand type

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Ligand		Description
		1. Ligand: RAP × 1 sirolimus Rapamycin immunosuppressant drug PDB code: 6m4u(B).

Cluster 4 contains 1 ligand type

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Ligand		Description
		1. Ligand: IHP × 2 Inositol hexakisphosphate PDB codes: 6zwm(A), 6zwo(B).

Cluster 5 contains 2 ligand types

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Ligand		Description
_Zn		1. Metal: _ZN × 1 PDB code: 6m4u(B).
		2. Ligand: SO4 × 2 Sulfate ion PDB codes: 4drh(B),

Cluster 6 contains 2 ligand types

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Ligand		Description
_Zn		1. Metal: _ZN × 1 PDB code: 6m4u(B).
		2. Ligand: SO4 × 1 Sulfate ion PDB code: 4drh(E).