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Ligand clusters for UniProt code P37231

Ligand clusters for P37231: Peroxisome proliferator-activated receptor gamma from Homo sapiens

Top 6 (of 23) ligand clusters


Cluster 1. 201 ligand types 324 ligands		Cluster 2. 1 ligand type 1 ligand		Cluster 3. 1 ligand type 1 ligand		Cluster 4. 2 ligand types 3 ligands		Cluster 5. 1 ligand type 1 ligand		Cluster 6. 1 ligand type 1 ligand

Representative protein: 3e00D

JSmol

Structures

PDB		Schematic diagram

3e00D
3v9yA
3dzuD
3v9tA
6ms7A
		more ...

Cluster 1 contains 201 ligand types (of which only 20 are listed. Click for all)

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Ligand

Description

1. Ligand: BRL × 14

rosiglitazone

2,4-Thiazolidiinedione, 5-[[4-[2-(Methyl-2- Pyridinylamino)ethoxy]phenyl]methyl]-(9cl)

PDB codes: 1fm6(D), 1zgy(A), 2prg(A), 3cs8(A), 3dzy(D), 4ema(A), 4o8f(A), 4xld(A), 5ji0(D), 5ycp(A), 6md4(A), 6onj(A), 7awc(A).

2. Ligand: GOL × 8

glycerin

Glycerol

PDB codes: 2fvj(A), 4em9(B), 5gto(A), 5gtp(A), 6d8x(A), 7awc(A).

3. Ligand: IMN × 6

indomethacin

Indomethacin

PDB codes: 3ads(A), 3adx(A), 4xum(A),

4. Ligand: DIF × 2

diclofenac

2-[2,6-Dichlorophenyl)amino]benzeneacetic acid

PDB codes: 4oj4(A), 4xta(A).

5. Ligand: 486 × 1

mifepristone

11-(4-Dimethylamino-Phenyl)-17-Hydroxy-13-Methyl-17- Prop-1-Ynyl-1,2,6,7,8,11,12,13,14,15,16,17-
Dodec ahydro-Cyclopenta[a]phenanthren-3-One

PDB code: 3qt0(A).

6. Ligand: 8N6 × 1

pioglitazone

(5s)-5-[[4-[2-(5-Ethylpyridin-2-Yl) ethoxy]phenyl]methyl]-1,3-Thiazolidine-2,4-Dione

PDB code: 5y2o(A).

7. Ligand: CIT × 1

citric acid

Citric acid

PDB code: 7awd(A).

8. Ligand: GD4 × 1

troglitazone

(5s)-5-[(4-{[(2r)-6-Hydroxy-2,5,7,8-Tetramethyl-3,4- Dihydro-2h-1-Benzopyran-2-
Yl]methoxy}phenyl)methyl]-1, 3-Thiazolidine-2,4-Dione

PDB code: 6dgo(A).

9. Ligand: HXA × 1

doconexent

Docosa-4,7,10,13,16,19-Hexaenoic acid

PDB code: 2vv0(A).

10. Ligand: STI × 1

imatinib

4-(4-Methyl-Piperazin-1-Ylmethyl)-N-[4-Methyl-3-(4- Pyridin-3-Yl-Pyrimidin-2-Ylamino)-Phenyl]-
Benzamide

PDB code: 6ktn(A).

11. Ligand: TLS × 1

telmisartan

4'-[(1,7'-Dimethyl-2'-Propyl-1h,3'H-2,5'- Bibenzimidazol-3'-Yl)methyl]biphenyl-2-Carboxylic acid

PDB code: 3vn2(A).

12. Ligand: TRS × 1

tromethamine

2-Amino-2-Hydroxymethyl-Propane-1,3-Diol

PDB code: 2p4y(A).

13. Ligand: KNA × 14

Nonanoic acid

PDB codes: 3sz1(A), 4em9(A), 5ugm(A), 6aug(A), 6avi(A), 6c1i(A), 6dh9(A), 6dha(A), 6o67(A).

14. Ligand: EDK × 10

(2~{s})-3-[4-[2-[Methyl(pyridin-2-Yl) amino]ethoxy]phenyl]-2-[[2-
(Phenylcarbonyl) phenyl]amino]propanoic acid

PDB codes: 6d8x(A), 6d94(A), 6fzf(A), 6fzg(A), 6fzj(A), 6fzp(A), 6t1s(A), 6t1v(A), 6vzl(A), 7jqg(A).

15. Ligand: LRG × 7

(2s)-2-(Biphenyl-4-Yloxy)-3-Phenylpropanoic acid

PDB codes: 3b3k(A), 3d6d(A), 4l96(A), 4l98(A),

16. Ligand: HIS-LYS-ILE-LEU-HIS-ARG-LEU-LEU-GLN-GLU × 6

PDB codes: 5dv3(A), 5dv6(A), 5dv8(A), 5dwl(A), 5gtn(A), 6ktm(A).

17. Ligand: MYI × 6

(5-Methoxy-1h-Indol-3-Yl)acetic acid

PDB codes: 3adu(A), 3adw(A).

18. Ligand: GW9 × 5

2-Chloro-5-Nitro-N-Phenylbenzamide

PDB codes: 3b0r(A), 3e00(D), 6avi(A), 6md2(A).

19. Ligand: SER-LEU-LEU-LYS-LYS-LEU-LEU-LEU-ALA-PRO × 5

PDB codes: 3v9t(A), 5z5s(A), 5z6s(A), 6izm(A), 6izn(A).

20. Ligand: HIS-LYS-LEU-VAL-GLN-LEU-LEU-THR-THR-THR × 4

PDB codes: 2fvj(A), 2gtk(A), 3fej(A), 3g9e(A).

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Cluster 4 contains 2 ligand types

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Ligand

Description

1. Ligand: GOL × 2

glycerin

Glycerol

PDB codes: 7awc(A), 7awd(A).

2. Ligand: SO4 × 1

Sulfate ion

PDB code: 3cs8(A).