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Ligand clusters for UniProt code P30291

Ligand clusters for P30291: Wee1-like protein kinase from Homo sapiens

Top 6 (of 16) ligand clusters


Cluster 1. 22 ligand types 22 ligands		Cluster 2. 3 ligand types 5 ligands		Cluster 3. 3 ligand types 4 ligands		Cluster 4. 1 ligand type 1 ligand		Cluster 5. 1 ligand type 3 ligands		Cluster 6. 2 ligand types 4 ligands

Representative protein: 2z2wA

Structures

PDB		Schematic diagram

2z2wA
2io6A
2in6A
3bizA
3cr0A
		more ...

Cluster 1 contains 22 ligand types (of which only 20 are listed. Click for all)

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Ligand

Description

1. Ligand: DB8 × 1

bosutinib

4-[(2,4-Dichloro-5-Methoxyphenyl)amino]-6-Methoxy-7-[3- (4-Methylpiperazin-1-Yl)propoxy]quinoline-
3- Carbonitrile

PDB code: 5vc3(A).

_Mg

2. Metal: _MG × 1

PDB code: 1x8b(A).

3. Ligand: 824 × 1

9-Hydroxy-4-Phenylpyrrolo[3,4-C]carbazole-1,3(2h,6h)- Dione

PDB code: 1x8b(A).

4. Ligand: 839 × 1

3-(9-Hydroxy-1,3-Dioxo-4-Phenyl-2,3-Dihydropyrrolo[3, 4-C]carbazol-6(1h)-Yl)propanoic acid

PDB code: 2in6(A).

5. Ligand: 330 × 1

9-Hydroxy-6-(3-Hydroxypropyl)-4-(2-Methoxyphenyl) pyrrolo[3,4-C]carbazole-1,3(2h,6h)-Dione

PDB code: 2io6(A).

6. Ligand: 61E × 1

4-(2-Chlorophenyl)-8-[3-(Dimethylamino)propoxy]-9- Hydroxy-6-Methylpyrrolo[3,4-C]carbazole-
1,3(2h,6h)- Dione

PDB code: 3biz(A).

7. Ligand: 34W × 1

N-{2-[(1s,4r)-6-{[4-(Cyclobutylamino)-5- (Trifluoromethyl)pyrimidin-2-Yl]amino}-1,2,3,4-
Tetrahydro-1,4-Epiminonaphthalen-9-Yl]-2- Oxoethyl}acetamide

PDB code: 5vd2(A).

8. Ligand: 396 × 1

4-(2-Chlorophenyl)-9-Hydroxy-6-Methyl-1,3-Dioxo-N-(2- Pyrrolidin-1-Ylethyl)pyrrolo[3,4-G]carbazole-
8- Carboxamide

PDB code: 3bi6(A).

9. Ligand: 770 × 1

N-[4-(2-Chlorophenyl)-1,3-Dioxo-1,2,3,6- Tetrahydropyrrolo[3,4-C]carbazol-9-Yl]formamide

PDB code: 2z2w(A).

10. Ligand: 809 × 1

4-(2-Chlorophenyl)-8-(2-Hydroxyethyl)-6- Methylpyrrolo[3,4-E]indole-1,3(2h,6h)-Dione

PDB code: 3cr0(A).

11. Ligand: 8X7 × 1

1-[6-(2-Hydroxypropan-2-Yl)pyridin-2-Yl]-6-{[4-(4- Methylpiperazin-1-Yl)phenyl]amino}-2-(Prop-2-En-
1-Yl)- 1,2-Dihydro-3h-Pyrazolo[3,4-D]pyrimidin-3-One

PDB code: 5v5y(A).

12. Ligand: 96M × 1

6-(2,6-Dichlorophenyl)-2-({4-[2-(Diethylamino) ethoxy]phenyl}amino)-8-Methylpyrido[2,3-D]pyrimidin-
7(8h)-One

PDB code: 5vc5(A).

13. Ligand: 98D × 1

1-{6-[(1s)-1-Hydroxyethyl]pyridin-2-Yl}-6-{[4-(4- Methylpiperazin-1-Yl)phenyl]amino}-2-(Prop-2-En-
1-Yl)- 1,2-Dihydro-3h-Pyrazolo[3,4-D]pyrimidin-3-One

PDB code: 5vda(A).

14. Ligand: 98G × 1

1-{6-[(1r)-1-Hydroxyethyl]pyridin-2-Yl}-6-{[4-(4- Methylpiperazin-1-Yl)phenyl]amino}-2-(Prop-2-En-
1-Yl)- 1,2-Dihydro-3h-Pyrazolo[3,4-D]pyrimidin-3-One

PDB code: 5vd9(A).

15. Ligand: 98M × 1

6-{[3-Chloro-4-(4-Methylpiperazin-1-Yl)phenyl]amino}-1- [6-(2-Hydroxypropan-2-Yl)pyridin-2-Yl]-2-
(Prop-2-En-1- Yl)-1,2-Dihydro-3h-Pyrazolo[3,4-D]pyrimidin-3-One

PDB code: 5vd8(A).

16. Ligand: 99J × 1

6-{[4-(4-Methylpiperazin-1-Yl)phenyl]amino}-2-(Prop-2- En-1-Yl)-1-{6-[(1s)-2,2,2-Trifluoro-1-
Hydroxyethyl]pyridin-2-Yl}-1,2-Dihydro-3h-Pyrazolo[3, 4-D]pyrimidin-3-One

PDB code: 5vd4(A).

17. Ligand: 99M × 1

1-[6-(2-Hydroxypropan-2-Yl)pyridin-2-Yl]-6-{[4- (Morpholin-4-Yl)phenyl]amino}-2-(Prop-2-En-1-Yl)-
1,2- Dihydro-3h-Pyrazolo[3,4-D]pyrimidin-3-One

PDB code: 5vd5(A).

18. Ligand: 99V × 1

6-{[3-Fluoro-4-(4-Methylpiperazin-1-Yl)phenyl]amino}-1- [6-(2-Hydroxypropan-2-Yl)pyridin-2-Yl]-2-
(Prop-2-En-1- Yl)-1,2-Dihydro-3h-Pyrazolo[3,4-D]pyrimidin-3-One

PDB code: 5vd7(A).