Ligand clusters for UniProt code P07711

Ligand clusters for P07711: Cathepsin L1 OS=Homo sapiens OX=9606 GN=CTSL PE=1 SV=2

		Top 6 (of 32) ligand clusters Cluster 1. 39 ligand types 81 ligands Cluster 2. 5 ligand types 6 ligands Cluster 3. 5 ligand types 7 ligands Cluster 4. 1 ligand type 1 ligand Cluster 5. 3 ligand types 6 ligands Cluster 6. 3 ligand types 4 ligands
Representative protein: 6jd0A

Structures

PDB		Schematic diagram
6jd0A
2yjbA
6jd8A
3of8A
3hwnA
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Cluster 1 contains 39 ligand types (of which only 20 are listed. Click for all)

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Ligand		Description
		1. Ligand: GOL × 16 glycerin Glycerol PDB codes: 2xu4(A), 2yj2(A), 2yj8(A), 2yj9(A), 2yjb(A), 3iv2(A), 4axl(A), 4axm(A), 5f02(A), 6ezp(A), 6jd0(A),
		2. Ligand: POL × 4 propyl alcohol N-Propanol PDB codes: 6jd0(A),
		3. Ligand: SO4 × 7 Sulfate ion PDB codes: 2vhs(A), 3iv2(A), 5i4h(A),
		4. Ligand: EDO × 5 1,2-Ethanediol PDB codes: 5mae(A), 5mqy(A), 6jd0(A), 6jd8(A).
_Zn		5. Metal: _ZN × 5 PDB codes: 4axl(A), 6f06(A),
		6. Ligand: BP4-CYS-DAR × 3 BP4=Biphenyl-4-Ylacetic acid, DAR=D-Arginine. PDB codes: 1mhw(A),
		7. Ligand: PGE × 3 Triethylene glycol PDB codes: 6jd0(A), 6jd8(A).
		8. Ligand: 424 × 2 (2s,4r)-1-[1-(4-Chlorophenyl)cyclopropyl]carbonyl -4-(2-Chlorophenyl)sulfonyl-N-[1- (Iminomethyl) cyclopropyl]pyrrolidine-2-Carboxamide PDB codes: 2xu1(A), 2yjc(A).
		9. Ligand: BP4-CYS-DAR-TYR-PEA × 2 BP4=Biphenyl-4-Ylacetic acid, DAR=D-Arginine, PEA=2-Phenylethylamine. PDB codes: 1mhw(A),
		10. Ligand: NSZ × 2 N-(Biphenyl-4-Ylacetyl)-S-Methyl-L-Cysteinyl-D-Arginyl- N-(2-Phenylethyl)-L-Phenylalaninamide PDB codes: 3h8c(A),
		11. Ligand: PO4 × 2 Phosphate ion PDB codes: 6jd0(A),
		12. Ligand: YJ9 × 2 (2s,4r)-4-(2-Chloro-Benzenesulfonyl)-1-[1-(4- Trifluoromethyl-Phenyl)-Cyclopropanecarbonyl] - Pyrrolidine-2-Carboxylic acid (1- Iminomethyl-Cyclopropyl)-Amide PDB codes: 2yj9(A), 2yjb(A).
_Cl		13. Metal: _CL × 2 PDB codes: 2nqd(B), 6f06(A).
		14. Ligand: 5T9 × 1 (2~{s},4~{r})-4-[(2-Chloranyl-4-Methoxy-Phenyl)- Bis(oxidanyl)-L^{4}-Sulfanyl]-1-[3-(5- Chloranylpyridin-2-Yl)azetidin-3-Yl]carbonyl-~{N}-[1- (Iminomethyl)cyclopropyl]pyrrolidine-2- Carboxamide PDB code: 5f02(A).
		15. Ligand: 7KH × 1 ~{N}-Cyclopentyl-~{N}-(Imidazo[1,2-A]pyridin-2- Ylmethyl)-4-(Iminomethyl)-6-Morpholin-4-Yl-1,3,5- Triazin-2-Amine PDB code: 5maj(A).
		16. Ligand: 7KN × 1 [4-[Cyclopentyl(pyrazin-2-Ylmethyl)amino]-6-Morpholin- 4-Yl-1,3,5-Triazin-2-Yl]methylideneazanide PDB code: 5mae(A).
		17. Ligand: ACT × 1 Acetate ion PDB code: 3hha(A).
		18. Ligand: BD3 × 1 Nalpha-[(3-Tert-Butyl-1-Methyl-1h-Pyrazol-5-Yl) carbonyl]-N-[(2e)-2-Iminoethyl]-3-{5-[(Z)- Iminomethyl]-1,3,4-Oxadiazol-2-Yl}-L-Phenylalaninamide PDB code: 3hwn(A).
		19. Ligand: BTB × 1 2-[Bis-(2-Hydroxy-Ethyl)-Amino]-2- Hydroxymethyl-Propane-1,3-Diol PDB code: 2xu3(A).
		20. Ligand: C3E × 1 (3~{s},14~{e})-19-Chloranyl-~{N}-(1-Cyanocyclopropyl)- 5-Oxidanylidene-12,17-Dioxa-4- Azatricyclo[16.2.2.0^{6, 11}]docosa-1(21),6(11),7,9,14,18(22),19-Heptaene-3- Carboxamide PDB code: 6ezp(A).
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Cluster 2 contains 5 ligand types

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Ligand		Description
		1. Ligand: GOL × 2 glycerin Glycerol PDB codes: 6jd0(A), 6jd8(A).
		2. Ligand: POL × 1 propyl alcohol N-Propanol PDB code: 6jd0(A).
		3. Ligand: NSY × 1 N~2~,N~6~-Bis(biphenyl-4-Ylacetyl)-L-Lysyl-D-Arginyl-N- (2-Phenylethyl)-L-Phenylalaninamide PDB code: 3h8b(A).
		4. Ligand: PO4 × 1 Phosphate ion PDB code: 6jd0(A).
_Na		5. Metal: _NA × 1 PDB code: 6jd0(A).

Cluster 3 contains 5 ligand types

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Ligand		Description
		1. Ligand: GOL × 2 glycerin Glycerol PDB codes: 6jd0(A),
		2. Ligand: NAG × 2 n-acetylglucosamine N-Acetyl-D-Glucosamine PDB codes: 3iv2(A), 3k24(A).
		3. Ligand: EDO × 1 1,2-Ethanediol PDB code: 5mqy(A).
		4. Ligand: NDG-NAG × 1 NDG=2-(Acetylamino)-2-Deoxy-A-D-Glucopyranose, NAG=N-Acetyl-D-Glucosamine. PDB code: 2nqd(B).
		5. Ligand: PEG × 1 Di(hydroxyethyl)ether PDB code: 6jd8(A).

Cluster 4 contains 1 ligand type

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Ligand		Description
		1. Ligand: V65 × 1 4-[(4-Chlorobenzyl)(cyclohexyl)amino]-6- Morpholin-4-Yl-1,3,5-Triazine-2-Carboxamide PDB code: 4axm(A).

Cluster 5 contains 3 ligand types

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Ligand		Description
		1. Ligand: GOL × 2 glycerin Glycerol PDB codes: 2xu5(A), 6jd0(A).
		2. Ligand: EDO × 3 1,2-Ethanediol PDB codes: 5mae(A), 5maj(A), 5mqy(A).
		3. Ligand: PGE × 1 Triethylene glycol PDB code: 6jd0(A).

Cluster 6 contains 3 ligand types

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Ligand		Description
		1. Ligand: GOL × 1 glycerin Glycerol PDB code: 6jd0(A).
		2. Ligand: EDO × 2 1,2-Ethanediol PDB codes: 5mae(A), 6jd0(A).
		3. Ligand: PGE × 1 Triethylene glycol PDB code: 6jd0(A).