Ligand clusters for UniProt code P00491

Ligand clusters for P00491: Purine nucleoside phosphorylase OS=Homo sapiens OX=9606 GN=PNP PE=1 SV=2

		Top 6 (of 20) ligand clusters Cluster 1. 21 ligand types 69 ligands Cluster 2. 3 ligand types 7 ligands Cluster 3. 2 ligand types 17 ligands Cluster 4. 3 ligand types 18 ligands Cluster 5. 2 ligand types 3 ligands Cluster 6. 2 ligand types 3 ligands
Representative protein: 1ulaA

Structures

PDB		Schematic diagram
1ulaA
5etjA
3phbE
4eb8A
3inyA
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Cluster 1 contains 21 ligand types (of which only 20 are listed. Click for all)

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Ligand		Description
		1. Ligand: PO4 × 5 Phosphate ion PDB codes: 1rr6(A), 2oc4(A), 2oc9(A), 2q7o(E), 3bgs(A).
		2. Ligand: GUN × 2 Guanine PDB codes: 1ulb(A), 1v2h(E).
		3. Ligand: 2DI × 1 didanosine 9-[(2r,5r)-5-(Hydroxymethyl)tetrahydrofuran-2-Yl]-1,9- Dihydro-6h-Purin-6-One PDB code: 1v3q(E).
		4. Ligand: AC2 × 1 acyclovir 9-Hyroxyethoxymethylguanine PDB code: 1pwy(E).
		5. Ligand: 3DG × 1 9-(3-Deoxy-Beta-D-Ribofuranosyl)guanine PDB code: 1v45(E).
		6. Ligand: NOS × 1 Inosine PDB code: 1rct(E).
		7. Ligand: MSG × 1 7-Methyl-6-Thio-Guanosine PDB code: 1yry(E).
		8. Ligand: AZG × 1 5-Amino-1h-[1,2,3]triazolo[4,5-D]pyrimidin-7-Ol PDB code: 1v41(E).
		9. Ligand: IMH × 7 1,4-Dideoxy-4-Aza-1-(S)-(9-Deazahypoxanthin-9-Yl)-D- Ribitol PDB codes: 1pf7(E), 1rr6(A), 1rt9(A), 2oc4(A), 2oc9(A), 2on6(A), 2q7o(E).
		10. Ligand: DIH × 5 7-[[(3r,4r)-3-(Hydroxymethyl)-4-Oxidanyl-Pyrrolidin-1- Ium-1-Yl]methyl]-3,5-Dihydropyrrolo[3,2- D]pyrimidin-4- One PDB codes: 1rsz(A), 2a0w(A), 2a0x(A), 2a0y(A), 3bgs(A).
		11. Ligand: SO4 × 24 Sulfate ion PDB codes: 1m73(E), 1pf7(E), 1pwy(E), 1rct(E), 1rfg(E), 1rsz(A), 1rt9(A), 1ula(A), 1ulb(A), 1v2h(E), 1v3q(E), 1v41(E), 1v45(E), 1yry(E), 2a0w(A), 2a0x(A), 2a0y(A), 3d1v(A), 3gb9(A), 3ggs(A), 3iny(A), 3k8o(E).
		12. Ligand: PO4 × 7 Phosphate ion PDB codes: 3k8q(A), 3phb(E), 4ear(A), 4eb8(A), 4gka(A), 5etj(A), 5ugf(A).
		13. Ligand: IM5 × 5 2-Amino-7-{[(3r,4r)-3-Hydroxy-4-(Hydroxymethyl) pyrrolidin-1-Yl]methyl}-3,5-Dihydro-4h-Pyrrolo[3,2- D]pyrimidin-4-One PDB codes: 3phb(E), 4ear(A), 4eb8(A), 5etj(A), 5ugf(A).
		14. Ligand: GUN × 1 Guanine PDB code: 4ece(A).
		15. Ligand: 229 × 1 7-({[(1r,2s)-2,3-Dihydroxy-1-(Hydroxymethyl) propyl]amino}methyl)-3,5-Dihydro-4h-Pyrrolo[3,2- D]pyrimidin-4-One PDB code: 3k8o(E).
		16. Ligand: 22A × 1 7-({[2-Hydroxy-1-(Hydroxymethyl)ethyl]amino}methyl)-3, 5-Dihydro-4h-Pyrrolo[3,2-D]pyrimidin-4-One PDB code: 3k8q(A).
		17. Ligand: 2FD × 1 5-(6-Amino-2-Fluoro-Purin-9-Yl)-2-Hydroxymethyl- Tetrahydro-Furan-3-Ol PDB code: 3ggs(A).
		18. Ligand: 7DG × 1 7-Deazaguanine PDB code: 3iny(A).
		19. Ligand: A2F × 1 2-Fluoroadenine PDB code: 3gb9(A).
		20. Ligand: D1V × 1 2-Mercapto(3h)quinazolinone PDB code: 3d1v(A).
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Cluster 2 contains 3 ligand types

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Ligand		Description
		1. Ligand: IM5 × 5 2-Amino-7-{[(3r,4r)-3-Hydroxy-4-(Hydroxymethyl) pyrrolidin-1-Yl]methyl}-3,5-Dihydro-4h-Pyrrolo[3,2- D]pyrimidin-4-One PDB codes: 3phb(E), 4ear(A), 4eb8(A), 5etj(A), 5ugf(A).
		2. Ligand: 229 × 1 7-({[(1r,2s)-2,3-Dihydroxy-1-(Hydroxymethyl) propyl]amino}methyl)-3,5-Dihydro-4h-Pyrrolo[3,2- D]pyrimidin-4-One PDB code: 3k8o(E).
		3. Ligand: 2FD × 1 5-(6-Amino-2-Fluoro-Purin-9-Yl)-2-Hydroxymethyl- Tetrahydro-Furan-3-Ol PDB code: 3ggs(A).

Cluster 3 contains 2 ligand types

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Ligand		Description
		1. Ligand: SO4 × 14 Sulfate ion PDB codes: 1m73(E), 1pf7(E), 1pwy(E), 1rct(E), 1rfg(E), 1v2h(E), 1v3q(E), 1v41(E), 1v45(E), 1yry(E), 3gb9(A), 3ggs(A), 3iny(A), 3k8o(E).
		2. Ligand: PO4 × 3 Phosphate ion PDB codes: 3phb(E), 5etj(A), 5ugf(A).

Cluster 4 contains 3 ligand types

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Ligand		Description
		1. Ligand: PO4 × 3 Phosphate ion PDB codes: 1rr6(A), 3bgs(A).
		2. Ligand: SO4 × 11 Sulfate ion PDB codes: 1rsz(A), 1rt9(A), 2a0w(A), 2a0x(A), 2a0y(A), 3d1v(A), 3gb9(A), 3ggs(A), 3k8o(E).
		3. Ligand: PO4 × 4 Phosphate ion PDB codes: 3k8q(A), 3phb(E), 5etj(A), 5ugf(A).

Cluster 5 contains 2 ligand types

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Ligand		Description
		1. Ligand: SO4 × 2 Sulfate ion PDB codes: 3gb9(A), 3ggs(A).
		2. Ligand: PO4 × 1 Phosphate ion PDB code: 5ugf(A).

Cluster 6 contains 2 ligand types

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Ligand		Description
		1. Ligand: SO4 × 2 Sulfate ion PDB codes: 3gb9(A), 3ggs(A).
		2. Ligand: PO4 × 1 Phosphate ion PDB code: 5ugf(A).