Ligand clusters for UniProt code P00374

Ligand clusters for P00374: Dihydrofolate reductase from Homo sapiens

		Top 6 (of 25) ligand clusters Cluster 1. 68 ligand types 203 ligands Cluster 2. 2 ligand types 2 ligands Cluster 3. 2 ligand types 15 ligands Cluster 4. 4 ligand types 8 ligands Cluster 5. 2 ligand types 3 ligands Cluster 6. 2 ligand types 2 ligands
Representative protein: 1bozA

Structures

PDB		Schematic diagram
1bozA
1hfqA
1kmvA
3nxyA
1yhoA
		more ...

Cluster 1 contains 68 ligand types (of which only 20 are listed. Click for all)

Use checkboxes to select ligands to display in RasMol, Jmol, or download as an SDF file. Selection shortcuts: select all/none invert selection.
Ligand		Description
		1. Ligand: NDP × 12 Nadph dihydro-Nicotinamide-Adenine-Dinucleotide phosphate PDB codes: 1boz(A), 1dlr(A), 1dls(A), 1kms(A), 1kmv(A), 1ohj(A), 1ohk(A), 1pd8(A), 1u72(A), 1yho(A), 2c2s(A), 2c2t(A).
		2. Ligand: NAP × 1 Nadp nicotinamide-Adenine-Dinucleotide phosphate PDB code: 1s3w(A).
		3. Ligand: FOL × 7 folic acid Folic acid PDB codes: 1dhf(A), 1drf(A), 2w3b(A), 2w3m(A), 4m6k(A), 6vcj(A), 7ese(A).
		4. Ligand: TOP × 5 trimethoprim Trimethoprim PDB codes: 2w3a(A), 3n0h(A), 3s3v(A),
		5. Ligand: GOL × 2 glycerin Glycerol PDB codes: 3ghv(A), 6de4(A).
		6. Ligand: DMS × 1 dimethyl sulfoxide Dimethyl sulfoxide PDB code: 1kmv(A).
_Mg		7. Metal: _MG × 1 PDB code: 4kfj(A).
		8. Ligand: DZF × 1 5-Deazafolic acid PDB code: 2dhf(A).
		9. Ligand: MTX × 2 Methotrexate PDB codes: 1dls(A), 1u72(A).
		10. Ligand: MOT × 3 N-[4-[(2,4-Diaminofuro[2,3d]pyrimidin-5-Yl) methyl]methylamino]-Benzoyl]-L-Glutamate PDB codes: 1hfp(A), 1hfq(A), 1hfr(A).
		11. Ligand: COP × 2 N-(4-Carboxy-4-{4-[(2,4-Diamino-Pteridin-6-Ylmethyl)- Amino]-Benzoylamino}-Butyl)-Phthalamic acid PDB codes: 1ohj(A), 1ohk(A).
		12. Ligand: LIH × 1 6-([5-Quinolylamino]methyl)-2,4-Diamino-5- Methylpyrido[2,3-D]pyrimidine PDB code: 1kms(A).
		13. Ligand: CO4 × 2 2,4-Diamino-5-Methyl-6-[(3,4,5-Trimethoxy-N- Methylanilino)methyl]pyrido[2,3-D]pyrimidine PDB codes: 1pd8(A), 1pd9(A).
		14. Ligand: PRD × 1 N6-(2,5-Dimethoxy-Benzyl)-N6-Methyl-Pyrido[2,3- D]pyrimidine-2,4,6-Triamine PDB code: 1boz(A).
		15. Ligand: DTM × 2 2,4-Diamino-6-[N-(3',4',5'-Trimethoxybenzyl)-N- Methylamino]pyrido[2,3-D]pyrimidine PDB codes: 1mvs(A), 1mvt(A).
		16. Ligand: TQD × 2 (2r,6s)-6-{[Methyl(3,4,5-Trimethoxyphenyl) amino]methyl}-1,2,5,6,7,8-Hexahydroquinazoline-2,4- Diamine PDB codes: 1s3u(A), 1s3v(A).
		17. Ligand: TQT × 1 6-(Octahydro-1h-Indol-1-Ylmethyl)decahydroquinazoline- 2,4-Diamine PDB code: 1s3w(A).
		18. Ligand: MXA × 2 6-(2,5-Dimethoxy-Benzyl)-5-Methyl-Pyrido[2,3- D]pyrimidine-2,4-Diamine PDB codes: 1dlr(A), 1u71(A).
		19. Ligand: LII × 1 (Z)-6-(2-[2,5-Dimethoxyphenyl]ethen-1-Yl)-2,4-Diamino- 5-Methylpyrido[2,3-D]pyrimidine PDB code: 1kmv(A).
		20. Ligand: TRR × 1 2,4-Diamino-5-(3,4,5-Trimethoxy-Benzyl)-Pyrimidin-1- Ium PDB code: 1yho(A).
+ more. Press for full list

Cluster 2 contains 2 ligand types

Selection shortcuts: select all/none invert selection.
Ligand		Description
		1. Ligand: DTT × 1 2,3-Dihydroxy-1,4-Dithiobutane PDB code: 4m6l(A).
		2. Ligand: SO4 × 1 Sulfate ion PDB code: 4m6l(A).

Cluster 3 contains 2 ligand types

Selection shortcuts: select all/none invert selection.
Ligand		Description
		1. Ligand: GOL × 1 glycerin Glycerol PDB code: 2w3a(A).
		2. Ligand: SO4 × 14 Sulfate ion PDB codes: 3eig(A), 3f8y(A), 3ghv(A), 3gyf(A), 3l3r(A), 3n0h(A), 3nxo(A), 3nxr(A), 3nxt(A), 3nxv(A), 3nxy(A), 3oaf(A), 3s3v(A), 4qhv(A).

Cluster 4 contains 4 ligand types

Selection shortcuts: select all/none invert selection.
Ligand		Description
_Mg		1. Metal: _MG × 1 PDB code: 4kbn(A).
		2. Ligand: SO4 × 5 Sulfate ion PDB codes: 3f8z(A), 3ghc(A), 3ghv(A), 3ntz(A), 3nxr(A).
		3. Ligand: EDO × 1 1,2-Ethanediol PDB code: 6dav(A).
_Cl		4. Metal: _CL × 1 PDB code: 4kfj(A).

Cluster 5 contains 2 ligand types

Selection shortcuts: select all/none invert selection.
Ligand		Description
		1. Ligand: GOL × 2 glycerin Glycerol PDB codes: 4m6k(A), 6de4(A).
_Ca		2. Metal: _CA × 1 PDB code: 4kak(A).

Cluster 6 contains 2 ligand types

Selection shortcuts: select all/none invert selection.
Ligand		Description
		1. Ligand: SO4 × 1 Sulfate ion PDB code: 3eig(A).
_Cd		2. Metal: _CD × 1 PDB code: 3eig(A).