Figure 3.
Fig. 3. The CPA binding site in E2(CPA+CC) superimposed
with that of E2(TG+BHQ) viewed in stereo approximately
perpendicular to the membrane. Yellow, E2(CPA+CC); light green,
E2(TG+BHQ). Cylinders represent transmembrane helices (M1–M5).
The pink net represents an |F[obs]| – |F[calc]| electron
density map at 2.8-Å resolution contoured at 4 before
CPA (shown in ball-and-stick) was introduced into the atomic
model. Dotted lines show likely hydrogen bonds. The atomic model
is shown in stick representation for E2(CPA+CC). Side chains of
Asn-101 and Gln-56 also are shown for E2(TG+BHQ).
before
CPA (shown in ball-and-stick) was introduced into the atomic
model. Dotted lines show likely hydrogen bonds. The atomic model
is shown in stick representation for E2(CPA+CC). Side chains of
Asn-101 and Gln-56 also are shown for E2(TG+BHQ).