|
Figure 1.
Fig. 1. Stereo view of the peptide/inhibitor binding site
of prolyl oligopeptidase. A, octapeptide binding. B,
Z-Gly-Pro-OH binding to the S554A variant. The bound ligands are
shown darker than the protein residues. The SIGMAA (28) weighted
2mF[o]   F[c]
electron density using phases from the final model is contoured
at 1  level,
where represents
the root-mean-square electron density for the unit cell.
Contours more than 1.4 Å from any of the displayed atoms
have been removed for clarity. C, covalently bound inhibitor
Z-Pro-prolinal to Ser554 of the wild type enzyme (drawn from
Protein Data Bank code 1qfs (14)). Dashed lines indicate
hydrogen bonds (drawn with MolScript (29, 30)).
|
