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Figure 5.
Figure 5 Interactions of regulatory phosphates with the  C-helix.
(A) The PDK1 backbone is shown as a ribbon, with helix C
in the centre of the view. Key residues are shown as sticks with
carbons coloured orange. The sulfate ion and the phosphate on
the activation loop are also shown. A stick model of ATP is
shown with carbons coloured purple. Hydrogen bonds are shown as
black dotted lines. (B) Alignment of the amino acid sequence
forming part of the phosphate pocket on PDK1 with the equivalent
region of the indicated AGC kinases. The residues corresponding
to Lys76, Arg131, Thr148 and Gln150 of PDK1 are indicated in
bold.
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