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Figure 5.
Fig. 5. Superposition of the active sites and presumed
binding pockets of KAS I (dark gray sticks) and KAS II (white
sticks) in ball-and-stick representation. KAS I residues are
labelled with capital letters and KAS II residues in lower case,
those marked with ’ are from the other subunit in the dimer.
The Cα of KAS II Ile-108 overlaps with the Cα of KAS I
Gly-107, and its side chain points into the cavity in KAS I. The
KAS II structural equivalent to KAS I Met-197 is Gly-198. The
KAS II equivalent to Gln-113’ is Ile-114’ and the space
occupied by Glu-200 is partially filled by Phe-133’. Glu-200
and Gln-113’ are at the bottom of the KAS I cavity. The only
polar residue in the KAS II binding pocket is Thr-137’ which
is an alanine in KAS I.
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