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Figure 2.
Fig. 2. Comparison of structural elements composing the 2B4
cleft. (A) Clefts in the mammalian 2B4 (green) and the bacterial
154C1 (PDB ID code 1GWI [PDB]
, blue) P450s are composed of similar structural elements. (B)
In 2B4 (green) helices, F' and G' flex away from the B' helix,
whereas in 2C5 (yellow), they extend to form the roof of the
active site. For clarity, only the regions including helices B
through D, F through G, and I are shown. The heme is shown as a
stick figure.
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