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Figure 1.
Fig. 1. The proposed reaction steps in squalene-hopene
cyclases involving carbocationic intermediates. The general acid
B[1]:H protonates (H) squalene at C3, whereas the general base
B[2] deprotonates at C29 of the hopenyl cation. In a side
reaction, the cation is hydroxylated^ forming hopan-22-ol.
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