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Figure 7.
Changes in the position of the C helix and heme ligation upon
CPI binding shown in divergent (walleye) stereo. Residues in
helix C (ribbon) alter positions significantly between the 2B4
open (green) and the CPI closed (blue) conformations, resulting
in the loss of a hydrogen bond to the D ring propionate in the
open conformation. Hydrogen bonds between the D ring propionate
and helix C residues are indicated by dashed lines. Residues
Arg-98 (R98), Ser-430 (S430), Arg-434 (R434), and His-369 (H369)
have smaller changes in their positions and are labeled once
near the base of the side chain.
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