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Figure 6.
Figure 6. Models of β-lactam substrates bound in the active
site of the metallo-β-lactamase from B. fragilis. The
substrates, shown in magenta, are: (a) ampicillin, (b)
ceftazidime and (c) imipenem. The corresponding chemical
structures are displayed on the right. The coloring scheme is as
described in the legend of Figure 3a. In addition, the dark
blue dotted line shows the shared hydroxide's proposed line of
attack on the carbonyl carbon of the substrate. Figure 6.
Models of β-lactam substrates bound in the active site of the
metallo-β-lactamase from B. fragilis. The substrates, shown in
magenta, are: (a) ampicillin, (b) ceftazidime and (c) imipenem.
The corresponding chemical structures are displayed on the
right. The coloring scheme is as described in the legend of
[5]Figure 3a. In addition, the dark blue dotted line shows the
shared hydroxide's proposed line of attack on the carbonyl
carbon of the substrate.
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