Figure 5.
Fig. 5. Proposed L-Arg-assisted NOS oxygen activation. First,
substrate L-Arg (only guanidinium shown) donates a proton to
peroxo-iron, facilitating O-O bond cleavage and conversion to a
proposed oxo-iron(IV) -cation
radical species, which then rapidly hydroxylates the^ neutral
guanidinium to NOH-L-Arg, possibly through a radical-based^
mechanism (3).
-cation
radical species, which then rapidly hydroxylates the^ neutral
guanidinium to NOH-L-Arg, possibly through a radical-based^
mechanism (3).