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Figure 3.
Fig. 3. The K+ ion-binding site on the  subunit of
human BCKD. The metal ion is bound by two main-chain carbonyl
groups and by the side chains of Ser-161- , Thr-166-
, and
Gln-167- . The side
chain of Leu-164- and the
main-chain carbonyl group of Ser-162- make direct
contacts with cofactor TDP. The octahedral coordination of the
metal ion stabilizes the loop structure on the subunit
(residues 161-167) that is essential for the efficient binding
of the cofactor.
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