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Figure 3.
Figure 3 The interface between NGF and TrkA-d5. a, The
binding epitopes of NGF to its receptors TrkA and p75. NGF is
shown as a space-filling model, and TrkA-d5 in ribbon rendering.
The NGF residues in the interface with TrkA-d5 are colour-coded
in different shades of red, reflecting the percentage of
accessible surface buried in the interface (dark red, 75-100%;
orange, 50-75%; light orange, 25-50%; yellow, 0-25%). The
conserved and specificity patches in the interface are outlined
(circles: the two symmetrical specificity patches; ovals: the
two symmetrical common patches), and Arg 103 (in red) on each
NGF monomer is labelled. Loops L2 and L4, which are proposed to
interact with the linker between TrkA-d5 and the membrane, are
dark green. Residues important for binding to p75 (refs 12, 23)
are blue. b, Stereo view showing the environment of Arg 103 of
NGF in the conserved portion of the interface. c, Stereo view
showing interactions between the N terminus of NGF and the
specificity patch of TrkA-d5.
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