Figure 1 - full size

Figure 1.
Figure 1 Overall structure of the complex. a, b, Two orientations related by a rotation of 90° about the horizontal axis. The NGF monomers are red and blue; TrkA-d5 is green. The termini, some relevant loops and the secondary structure elements are labelled. In a, loops L2 and L4 of NGF and the C-terminus of TrkA-d5 (residue 382) point towards the membrane.