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Figure 7.
Figure 7. Proposed Mechanism for Pterin in NO
BiosynthesisThe uniqueness of the H[4]B–eNOS interaction
(Figure 4) and the ability to bind L-Arg at the pterin site
present a strong case for the involvement of a pterin radical in
NOS catalysis and rule out the possibility of H[4]B ↔ qH[2]B
cycling during NO biosynthesis. R represents the dihydroxypropyl
side chain at the C6 position on the pterin ring.
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