Figure 6 - full size

Figure 6.
Figure 6 Coordination of Mg2+ in the ATP-binding site of NAD^+ synthetase. The nicotinosyl moiety of NaAD is shown in violet, AMP in gold and PP[i] in red; Mg2+ with coordinated O atoms are shown in silver, relevant amino-acid residues are in green and the loop 204-225 is indicated by thin brown lines. Positions Mg(I), Mg(II) and Mg(III) are explained in the text. Coordination of the new Mg(III) position is indicated by thin silver lines. The new conformation of Glu162 at pH 7.5 is shown in cyan. ATP and AMP-CPP are not shown for clarity. Prepared with RIBBONS (Carson, 1997[Carson, M. (1997). Methods Enzymol. 277, 493-505.]).