Figure 5.
Figure 5 Homology model of the human TFE complex. (A) The
symmetric TFE architecture, with the mutation sites (red
spheres) relevant to various genetic diseases (Ibdah et al,
1998; Eaton et al, 2000). The arrowheads denote the HACD active
sites. The inset indicates Val282, located in the interface
between ECH in the -subunit
and KACT in the -subunit.
The insertion specific for TFE is depicted by dotted lines with
asterisks. (B) Electrostatic surface representation showing the
biased distribution of positive charges around the central
solvent region.
-subunit
and KACT in the 
-subunit.
The insertion specific for TFE is depicted by dotted lines with
asterisks. (B) Electrostatic surface representation showing the
biased distribution of positive charges around the central
solvent region.