|
Figure 4.
Figure 4. The Open and Closed Catalytic Center of HPPK(a)
The three uncoupled flexible loops of HPPK in the apo-enzyme
[2].(b) The coupling of these loops in the ternary complex. In
the ternary complex, a hydrogen-bond network involves N10 from
Loop-1; P47 and Q50 from Loop-2; and W89, P91, and R92 from
Loop-3. This network is not observed in apo-HPPK. The
orientation of the drawing is indicated by the position of the
substrate molecules HP and MgAMPCPP. (This figure was prepared
with the program MOLSCRIPT [21].)
|
