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Figure 4.
Fig. 4. The binding interface of the MBP-74 monobody and
MBP. (A) The monobody paratope residues are shown as stick
models, and the MBP epitope surface is shown in the same manner
as in Fig. 3D. The carbon atoms of BC, DE, and FG loop residues
of the monobody are in cyan, yellow, and green, respectively.
The oxygen and nitrogen atoms are shown in red and blue,
respectively. The monobody backbone is also shown as a
transparent cartoon model. (B) Interactions between the monobody
FG loop residues (stick models) and the MBP bottom lobe epitope
(shown as surfaces). The surfaces of aromatic residues are shown
in yellow. Potential polar interactions for the hydroxyl oxygen
atom of the paratope Tyr residues are shown as dashed lines with
their distances. The monobody residues are indicated in bold.
(C) The interactions in the top lobe epitope. MBP residues are
drawn with carbon atoms in gray. The carbon atoms of BC, DE, and
FG loop residues of the monobody are in cyan, yellow, and green,
respectively. (D) The buried surface areas of the monobody
residues. Only those for the binding complex are shown.
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