Figure 4.
FIG. 4. Polypeptide-backbone mobility in the structures of
p53 core domain quadruple mutant M133L/V203A/N239Y/N268D and
wild type. A, distribution of average isotropic B-factors for
main-chain atoms in chains A (thick solid line) and B (thin
solid line) of the quadruple mutant, and chain A (DNA-free) of
wild type (dotted line). Secondary structural elements are given
for reference; blocks represent -strands and open
circles indicate helical segments. B, relative backbone mobility
as calculated by (B-)/ [B] in chains A (thick
solid line) and B (thin solid line) of the superstable quadruple
mutant, and chain A (DNA-free) of wild type (dotted line). B-
is the deviation of the average isotropic main-chain B-factor
for a particular residue from the mean for the whole chain
(backbone atoms only), [B] the standard
deviation.
-strands and open
circles indicate helical segments. B, relative backbone mobility
as calculated by (B-)/ 
[B] in chains A (thick
solid line) and B (thin solid line) of the superstable quadruple
mutant, and chain A (DNA-free) of wild type (dotted line). B-
is the deviation of the average isotropic main-chain B-factor
for a particular residue from the mean for the whole chain
(backbone atoms only),