Figure 4 - full size

Figure 4.
Fig. 4. Detail of the heme-binding region of NP2. The view is from the back of the heme pocket. Hydrophobic residues lining the distal pocket are shown along with the distal ligand (either ammonia or water). On the proximal side of the heme, the ligand His^57 is shown along with the hydrogen bonding network involving Asn^67 and an intervening water molecule. Residues hydrogen bonding with the heme propionate groups are also shown. Oxygens are indicated by stippled spheres, and nitrogens are indicated by larger open spheres.