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Figure 4.
Figure 4. Surface Representation of SHC Sliced through the
Middle of the MoleculeThe surfaces are colored as nonpolar
(yellow) and positively (blue) and negatively (red) charged. The
large internal cavity is connected by a nonpolar channel to a
hydrophobic surface patch that dips into the membrane. The
channel constriction (C) permits substrate passage because
Phe434 and Cys435 are on a mobile loop. Ro48-8071 (major
conformation) occupies the active-center cavity and the channel
up to the constriction. Asp376 and Ala44 are shown as
ball-and-stick models.
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