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Figure 3.
Figure 3. Hydrogen bonding networks involving water molecules
W1-W9 (red spheres) located in the active site, linking the
flaps to the core of the enzyme. W1 is within hydrogen bonding
distances from carboxyl groups of both catalytic aspartic acids:
D25 and D1025. Such a water molecule is found in all native
structures of HIV PR and is implicated in nucleophilic attack on
the scissile peptide bond.
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