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Figure 3.
Fig. 3. (A) Stereo pair of the acetyl-ThDP moiety and the bound
CO[2 ]molecule of PFOR and their protein environment. (B) Stereo
pair of the superposition of a part of the active site of PFOR
in the uncomplexed (green), and radical forms. The movements of
the thiazole ring and the side chains of Asn996 and Tyr994 are
concerted, and the S1 atom from the thiazole ring keeps its
hydrogen bond to Asn996 in the two conformations. Part (A) was
prepared using Molscript (39) and Raster3d (40); (B) was
prepared with Turbo-Frodo (38).
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