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Figure 3.
FIG. 3. The structure of p53 core domain quadruple mutant
M133L/V203A/N239Y/N268D (chain A, yellow) superimposed on the
wild type structure (chain A, transparent light gray). A,
mutation site M133L; B, mutation site V203A; C, mutation site
N268D; D, mutation site N239Y. The zinc ion is shown as a gray
sphere. The large semi-transparent red spheres indicate the
location of the two cancer hot-spot sites Gly-245 and Arg-249.
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