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Figure 2.
A, divergent stereo view of the 2B4-bifonazole monomer.
Helices and strands are colored yellow and blue, respectively.
The termini and major helices are labeled. Heme, bifonazole, and
Cymal-5 molecules are shown as red, forest green, and cyan
sticks, respectively. B, the dimer interface of 2B4-bifonazole
is stabilized by interdigitating β-strands, and extra copies of
detergent and substrate that associate with exposed hydrophobic
regions. For clarity, only residues 98-117 and 204-230 are
shown. Molecules A and B are colored yellow and gray,
respectively. Heme is shown as red sticks. Bifonazole and
Cymal-5 of molecule A are shown as forest green and cyan sticks,
respectively. Bifonazole and Cymal-5 of molecule B are shown as
green and pale cyan sticks, respectively. Helix F′ and
β-strands 6-1, 7-1, 7-2, and 7-3 are labeled. The chemical
formula of Cymal-5 is shown.
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