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Figure 2.
Fig. 2. FIH-CAD interactions. a, CAD fragments are shown
as stick models in yellow above a van der Waals surface of FIH.
FIH residues beneath the surface are colored green. Dotted red
lines represent electrostatic bonds. b, alternative view of site
1. Note Asn803 is deeply buried. c, electron density for the
bound CAD peptide (structure 1). CAD residues 795-806 (site 1,
left) and 812-823 (site 2, right) are shown as ball-and-stick
representations in yellow. The difference electron density,
contoured at 2.2  (left) and
1.5 (right),
was calculated after random model perturbation and refinement
with CAD omitted to remove model bias.
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