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Figure 2.
Figure 2. Comparison of wild-type (yellow) and
Phe51Leu-stabilized (white) α[1]-antitrypsin. The Phe51Leu
mutation improves packing of 384Phe in the shutter domain of
α[1]-antitrypsin. This has little effect on the A β-sheet that
overlies this region but will hamper the movement of s2A and s3A
to accept exogenous reactive loop peptides.
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