Figure 2.
Figure 2 Agonist and antagonist binding modes. a, The 3.1-Å
resolution, six-fold averaged electron-density map (using model
phases) for the ER LBD-E[2] complex. b, The experimental, 2.6-Å
resolution electron-density map for the ER LBD-RAL complex after
DMMULTI multicrystal averaging. In both cases, the map is
contoured at 1 and
overlaid on the final refined models. c, d, Schematic
representation of the interactions made by E[2] (c) and RAL (d)
within the binding cavity. Residues that interact with ligand
and/or line the cavity are shown in theirapproximate positions.
Those that make direct hydrogen bonds are depictedin
ball-and-stick style with broken lines between the interacting
atoms.The hydrogen-bond distances shown are averaged between the
six (E[2]) or two (RAL) monomers. The atom names and ring
nomenclature of E[2] are also given.
and
overlaid on the final refined models. c, d, Schematic
representation of the interactions made by E[2] (c) and RAL (d)
within the binding cavity. Residues that interact with ligand
and/or line the cavity are shown in theirapproximate positions.
Those that make direct hydrogen bonds are depictedin
ball-and-stick style with broken lines between the interacting
atoms.The hydrogen-bond distances shown are averaged between the
six (E[2]) or two (RAL) monomers. The atom names and ring
nomenclature of E[2] are also given.