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Figure 2.
Figure 2. Ribbon Model of SHC with a Space-Filling Model of
Bound Ro48-8071Fluorine is green; bromine is purple. The inner
and outer helices are yellow and red, respectively. The channel
constriction residues, the putative catalytic acid Asp376 [4],
and the photolabeled Ala44 [18] are shown as light-green
ball-and-stick models. The nonpolar plateau, assumed to plunge
into the nonpolar membrane interior, consists of helices α8 and
3[10] as well as loops L6′, L8, and L15. It harbors the
channel entrance (E), indicated by a dotted line.
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