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Figure 1.
Figure 1. (a) Structure of the E9 DNase (red) bound to Im9
(yellow) at 1.7 Å superimposed on the original structure
reported by [Kleanthous et al 1999] at 2.05 Å (grey). The
N and C-terminus of each protein is indicated, and secondary
structure elements of Im9 are labelled. A phosphate molecule,
which identifies the active site of the enzyme, is present in
both structures. (b) Overlay of the H-N-H motif in the two
structures showing the local rearrangements of ligating
histidine side-chains that result from the absence of a divalent
cation at the active site. The metal ion is replaced with a
water molecule in the present structure.
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