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Figure 1.
A, structure of ligand-free 2B4. B, structure of 2B4-CPI. The
chemical formula of CPI is shown below the protein structure. C,
structure of 2B4-bifonazole. The chemical formula of bifonazole
is shown below the protein structure. The three structures are
shown in the same orientation by aligning the most conserved
tertiary structure (residues 61-98 and 306-465). Four regions
around the active site (residues 100-140, 203-262, 276-290, and
474-479) are colored green in A, orange in B, and yellow in C,
respectively, with the major helices labeled. Other parts of the
protein are colored gray in all three structures. Heme, CPI, and
bifonazole are shown as red, cyan, and forest green sticks,
respectively. Images were generated using PyMol (www.pymol.org)
unless otherwise credited.
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