Figure 1.
Figure 1: Quaternary rearrangements in the integrin ectodomain.
a -c, Three conformational states visualized in electron
microscopy3,6 and in crystal structures (here and in ref. 7). d
-j, Proposed intermediates in equilibration between known
conformational states. The upper pathways may be stimulated by
ligand binding outside the cell, and the lower pathways by
signals within the cell that separate the and
subunit
transmembrane domains. Domains in a -j are shown in solid colour
if known directly from crystal structures, dashed with grey if
placed from crystal structures into electron microscopy image
averages, and in solid grey for EGF-1 and EGF-2, which are
modelled on EGF-3 and EGF-4.
and
subunit
transmembrane domains. Domains in a -j are shown in solid colour
if known directly from crystal structures, dashed with grey if
placed from crystal structures into electron microscopy image
averages, and in solid grey for EGF-1 and EGF-2, which are
modelled on EGF-3 and EGF-4.