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Figure 1.
Figure 1: Structure of nSec1 and syntaxin 1a. a, Topology
diagram of nSec1. Domain 1 is shown in blue, domain 2 in green
and domain 3 in yellow. Helices are denoted by cylinders and
strands by arrows. Breaks in the structure are indicated with
asterisks. In domains 1 and 2, helices with dashed and solid
lines lie on opposite sides of the parallel  -sheet.
Note the left-handed crossover between strands 8
and 9.
Dashed outlines denote domains 3a and 3b. b, Ribbon
representation of nSec1, coloured as in a. c, d, Topology (c)
and ribbon diagrams (d) of syntaxin 1a. The Habc domain is shown
in red, the Habc/H3 linker in orange and the H3 region in
purple. The conformations of nSec1 and syntaxin 1a are as they
appear in the protein complex, but have been separated and
reorientated here for clarity. In b and d the approximate
dimensions are shown; the dimensions perpendicular to the plane
of the page are  45
Å for nSec1 and 35
Å for syntaxin 1a. Panels b and d were prepared with the program
MOLSCRIPT47, as were Figs 2 and 5. Secondary structure was
assigned by PROCHECK46.
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