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Figure 1.
Figure 1. The Three-Step Mechanism Characterizing the
Decarboxylating Claisen Condensing EnzymesThe first step is a
trans-thioesterification of the primer substrate. Subsequently,
malonyl-ACP gets decarboxylated to give the carbanion, which
then attacks C1 of the primer substrate, followed by release of
the product, 3-oxoacyl-ACP
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