Sequence alignment between 1rx8(A) and UniProt seq P0ABQ4 (DYR_ECOLI):

P0ABQ4 (DYR_ECOLI): Dihydrofolate reductase from Escherichia coli (strain K12)
                 10        20        30        40        50        60        70        80        90       100       110       120       130       140       150         
         ---------+---------+---------+---------+---------+---------+---------+---------+---------+---------+---------+---------+---------+---------+---------+---------
UniProt: MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR
         ....................................X..........................................................................................................................
PDB seq: MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLDKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR
         ---------+---------+---------+---------+---------+---------+---------+---------+---------+---------+---------+---------+---------+---------+---------+---------
                 10        20        30        40        50        60        70        80        90       100       110       120       130       140       150