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Figure 8.
Figure 8 Qualitative model of the HsGAPDH-Siah1 complex. (a)
Docked complex having the top score from PatchDock. A GAPDH
subunit is shown in green and the Siah1 dimer is shown in
cyan/violet. Only one subunit of the GAPDH dimer used for
docking is shown for clarity. GAPDH residues 222-240 are colored
gray. Siah1 residues 270-282 are colored yellow. GAPDH Lys227
and Siah1 Ser280 are drawn as spheres. (b) Model of a GAPDH
tetramer interacting with four Siah1 dimers. This model was
generated from the model in (a) using the symmetry of the GAPDH
tetramer. The view is looking down the GAPDH R axis. GAPDH
subunits are colored as follows: O, yellow; P, red; Q, green; R,
blue. Siah1 dimers are colored cyan/violet and salmon/slate. (c)
Surface representation of the model shown in (b).
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