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Figure 8.
FIG. 8. Schematic representation of the reaction mechanism
of ADPR hydrolysis. The reaction scheme was proposed based on
the active site architecture according to the structural and
functional analyses of TtADPRase. Reaction state I is the
metal-bound state, II is the ternary complex with substrate and
metal, III is the transition state, and IV is the product
release state. The nucleophilic attack and proton abstraction
events are shown by pink arrows.
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