|
Figure 8.
Fig. 8. A, representative structures (closest to average)
of each structure ensemble. The Glu-17 side chain is shown in
red. The hinge residue Abu-13 is shown in green. The structures
were fitted on backbone heavy atoms of residues 13-20 (colored
blue). The remainder of the structure is shown in gray. B,
surface electrostatic potential of mersacidin in different
sample conditions calculated with MOLMOL (40). Positive and
negative potentials are colored blue and red, respectively. The
structures are in the same orientation as in A. C, 90°
rotation along the x axis of the above structures. The charge
distributions reveal the increase of charge accessibility after
the addition of lipid II in the hydrophobic DPC micelle
solution. The structure of mersacidin in DPC micelles resembles
the x-ray structure that was solved in pure methanol.
|
