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Figure 7.
Fig. 7. Conformational changes in the active sites of AtMTAN1
(a) and EcMTAN (b) upon binding of FMA or MTT. (c)
Superimposition of EcMTAN-Ade and apo-AtMTAN1. Electron density
is missing for the β10-α6 loop in EcMTAN because of disorder,
so this region is not modeled in the structure and is
represented here by a dotted line. (d) Superimposition of
EcMTAN-MTT and AtMTAN1-MTT highlighting the positions of Phe148
in AtMTAN1 and Tyr107 in EcMTAN and their relative proximities
to the 5′-alkylthio end of the ligand. In all panels, the apo-
and MTT-bound structures of AtMTAN1 are shown in yellow and
brown, respectively, while the ADE- and MTT-bound forms of
EcMTAN are shown in gray and pink, respectively.
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