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Figure 7.
Figure 7 Structures of HsGAPDH and Siah1 highlighting regions
that are important for GAPDH-Siah1 association. (a) HsGAPDH
tetramer viewed down the R axis. Subunits are colored as
follows: O, yellow; P, red; Q, green; R, blue. Residues that are
essential for complex formation with Siah1 are colored gray
(residues 222-240) and atoms of Lys227 are drawn as spheres. (b)
Homodimer of Siah1 from PDB entry 1k2f (Polekhina et al.,
2002[Polekhina, G., House, C. M., Traficante, N., Mackay, J. P.,
Relaix, F., Sassoon, D. A., Parker, M. W. & Bowtell, D. D.
(2002). Nature Struct. Biol. 9, 68-75.]). The two subunits of
Siah1 are colored cyan and violet. Residues that are essential
for interaction with GAPDH are colored yellow (residues 270-282).
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