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Figure 7.
Figure 7. Common structural arrangement for
cobamide-dependent enzymes. (a). The cobalamin coordinates from
the 1bmt structure were used to manually dock the cobalamin
molecule into the TIM barrel cavity by avoiding van der Waals
clashes, but minimizing N5 to Co distance. (b) Interactions
between cobalamin and methylmalonyl-CoA mutase [59 and 60]. The
figures were produced using QUANTA (Molecular Simulations Inc.).
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