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Figure 6.
Figure 6. Comparison of the TolC and AcrA(45-312)-4M
Coiled-Coils
The magnitude of conformational change
predicted for the opening of the TolC channel coincides with the
flexibility observed in the AcrA a-helical hairpin domain. The
inner (yellow) and outer helices (blue) of TolC are shown
superposed based on the internal structural repeat (residues
16-98 and 222-316). Below these are molecules B (red) and C
(green) of AcrA(45-312)-4M, as superposed on the lipoyl domain.
Direct engagement of AcrA and TolC is not modeled.
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