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Figure 6.
FIG. 6. Locations of mutations identified in coproporphyria
patients. Shown is a worm representation stereo view of form II
(closed) structure in the same orientation as shown in Fig. 3A.
Sites of mutations identified in patients are shown as spheres.
Substitutions expected to destabilize the folded protein
structure are shown in gray. Mutations whose presumed
deleterious effect is not easily explained by the structure are
shown in blue. Mutations at the active-site cleft are shown in
magenta. The modeled substrate molecule (white) indicates the
approximate location of the active-site cavity.
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