|
Figure 6.
Figure 6. Flipping of PEP in the active site of DAHPS upon
Phe binding. The PEP coordinating sphere shown in the same
orientation in (a) -Phe and (b) +Phe DAHPS. H-bonds, shown as
dotted lines, are in the range of 2.8-3.3 Å. In both
forms, PEP also has p,p interaction with the imidazole ring of
His268. The thin gray trace in (b) represents superimposed PEP
from (a). Non-coordinating Lys97 and Arg165 (two conformers) are
shown in (b).
|
