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Figure 6.
Figure 6. (a) Structure and (2|F[o]| - |F[c]|), a[c] map
contoured at 1.0 and 2.4s for P2[1]2[1]2[1] (form b)
trypsin-APC-1144-Zn2+, pH 8.10, 1.37 Å resolution.
Coordinate bonds to the Zn2+ are cyan, and hydrogen bonds are
white. (b) Superposition of trypsin-APC-1144-Zn2+ (standard atom
coloring scheme) onto trypsin-APC-1144 (carbon, cyan; oxygen,
orange; and nitrogen, pink) shows a considerable change in the
position and orientation of the phenol ring of the inhibitor.
Coordinate and hydrogen bonds in the former are yellow, hydrogen
bonds in the latter are cyan.
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